Project Objectives
- • Evaluate serum homocysteine levels in ischaemic stroke patients.
- • Assess the association between HCY and functional outcome.
- • Examine the link between HCY levels and post-stroke depression.
Clinical Impact
- • Established HCY blood testing to clarify stroke cause in young patients.
- • Enables targeted treatment with folic acid for those with raised HCY.
- • Proper screening for post-stroke depression, leading to appropriate counseling and medication.
Community & Rehab
- • Evaluation of functional outcome pre and post-rehabilitation to optimize recovery plans.
- • Regular public talks provided education on stroke causes, management, and long-term outcome.
- • Provided support and counseling for patient careers to prevent burnout.
The Critical Challenge: Early Prediction & Intervention
Stroke is a leading cause of global disability. This study focused on the link between raised serum homocysteine (HCY)—a biomarker for atherosclerosis—and poor outcomes in younger stroke patients. High HCY is associated with increased stroke severity, unfavourable functional outcomes, and a higher risk of post-stroke depression. Early prediction of outcome in ischaemic stroke is crucial for effective intervention and improved long-term quality of life.
Maximizing Community Impact Through Collaboration
Project Leadership
Project Leader: Prof Madya Dr Tai Mei Ling Sharon
Department of Medicine, Faculty of Medicine, University of Malaya
Key Collaborators:
- Dr Toh Tsun Haw (Neurologist, UMMC)
- Dr Ong Kuo Ghee (Consultant Rehabilitation Physician, SOCSO)
Community & Scale
Target Community: Young stroke patients
Location: Tun Abdul Razak SOCSO Rehabilitation Center, Melaka
Involvement:
- Approx. 150 targeted community participants.
- 10 SOCSO staff partners (nurses, physiotherapists, doctors) involved in implementation.
- Total Project Cost: RM 15,000 (Grant & Contributions).